Limitations in the Application of Clinicopathologic Factors Alone in Predicting Radiation Benefit for Women With Low-Risk DCIS After Breast Conserving Surgery

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Limitations in the Application of Clinicopathologic Factors Alone in Predicting Radiation Benefit for Women With Low-Risk DCIS After Breast Conserving Surgery

By Frank Vicini

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February 23, 2024

Traditionally, clinicopathologic factors have been used to select which patients are eligible to de-escalate treatment, ...
read more ↘ but prospective trials have failed to identify a low risk clinpath group that did not benefit from RT with respect to local control. The objective of this study was to assess the reclassification and outcomes of patients with low-risk clinicopathologic factors into risk groups defined by DCISionRT, the 7-gene biosignature, and compared to 10-year IBR rates.
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