DCISionRT, the Only DCIS Test to Predict Radiation Therapy Benefit

Important DCISionRT News for Physicians and Patients

For Doctors

The Test

For Patients

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The DCIS Test That Enables Personalized Treatment

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DCISionRT enables physicians to deliver precision medicine to DCIS patients

In a multisite study including 474 DCIS patients, DCISionRT substantially reclassified DCIS patient risk compared to traditional clinicopathologic risk assessment, such as grade (shown). In fact, 53% of patients with low or intermediate grade DCIS (grade 1 or 2) were upstaged to elevated risk by DCISionRT and 30% of patients with high grade DCIS (grade 3) were identified as low risk by DCISionRT1. With DCISionRT, patients and physicians have access to a test that enables truly personalized treatment based on a patient’s individual biology.
Traditional risk assessment using DCIS grade to DCISionRT risk groups indicates the power of the DCISionScore. While traditional risk assessment with DCIS grade shows little difference for low/intermediate grade DCIS (grade 1 & 2) compared to high grade DCIS, DCISionRT distinguishes which patients have a clinically low risk (DCISionScore ≤3) from those with clinically elevated risk (DCISionScore >3). With DCISionRT, Know Your Risk™.

Results are shown are for the 196 patients treated with conserving surgery treated patients with clear margins in a multisite study. Total recurrence risks shown are adjusted for year of diagnosis. This was demonstrated in a multisite study of 474 patients1.

1 Bremer T, Whitworth P, Patel R, et al. . A biologic signature for breast ductal carcinoma in situ to predict radiation therapy (RT) benefit and assess recurrence risk. Clin Cancer Res . 2018; doi:10.1158/1078-0432.CCR-18-0842.