Pat Whitworth, MD, FACS

Breast Surgical Oncology Specialist, Director of the Nashville Breast Center

0:34 Clinical Need–takeaways from DCIS randomized landmark trials, RTOG, NCCN

Troy Bremer, PhD

Founder & Chief Scientific Officer of PreludeDx

5:08 Genomic Solution—DCISionRT
8:56 Who will recur despite BCS+RT?
9:42 Pathway for residual recurrence risk
10:52 About Residual Risk Subtype (RRt)

Chirag Shah, MD

Co-Director of Comprehensive Breast Program and Director of Clinical Research in the Department of Radiation Oncology at the Cleveland Clinic

11:15 Validation data of DCISionRT+RRt
14:20 Stratification for RT benefit and NNT
18:20 RRt clinpath subpopulations

Pat Whitworth, MD, FACS

Breast Surgical Oncology Specialist, Director of the Nashville Breast Center

19:05 Validation supporting true low risk and RT benefit groups
20:43 Age and grade Subpopulation analysis
23:40 Individualized patient care

Troy Bremer, PhD

Founder & Chief Scientific Officer of PreludeDx

24:00 Summary:  Supportive evidence
26:22 Real-world Case Studies

Panel Q and A Discussion

33:36 Addressing microcalcifications in study cohort
34:19 Local Recurrence rate vs metastatic rate in study cohort
35:06 Margins status and DS in study cohort and treatment implications
37:33 Hormone Receptor status in study cohort and treatment implications
41:55 Overcoming nuclear grade subjectivity
43:36 Management of patients meeting RTOG criteria
44:52 RT modalities
45:42 Implementing into clinical practice
48:15 Specimen type for testing
49:30 RRt vs Decision Score
50:25 RRt treatment implications
50:25 Closing statements from KOLs